Gut Health

Nutritional Support for Digestive Issues, IBS, Bloating, Acid Reflux, Overall Wellness, & More

Bathroom emergencies stink. And an angry gut can lead to more problems than just uncomfortable jeans. Enter Kettle & Fire. The gelatin and nutrients in our high-quality Bone Broths are the answer to all of your tummy troubles. From pain and bloating to more serious issues, we’ve got the sippable solutions to ease your stomach woes.

Digestion and Gut Health

Benefits of Bone Broth for Gut Health

Disorders of the digestive tract impact more than 60-70 million people in the US.1 Healthcare practitioners understand that the gastrointestinal (GI) tract is responsible for nutrient digestion and absorption, as well as ridding the body of waste, but the lower portion of the GI tract plays a number of other important roles in our health. 

Specifically, the microbiome, the integrity of the gut lining, and our immune system are all related to full body health.2–5 An imbalanced microbiome and poor gut integrity have been linked to a number of conditions, including:3,4,6–8

  • Autoimmune Disorders - including rheumatoid arthritis, type 1 diabetes, atopic dermatitis, and atopic asthma
  • Metabolic Diseases - such as cardiovascular disease and type 2 diabetes
  • Psychiatric Disorders
  • Inflammatory Bowel Disease

Leaky Gut

While leaky gut is not recognized as a medical disease, its main characteristic of intestinal permeability is a real symptom. Having a healthy intestinal barrier allows for the exchange of nutrients, water, and electrolytes through the epithelial cells while preventing the entry of pathogens.9,10 There are a number of things that can impact the health of the gut barrier, with nutrition being a key player.6,11

Bone Broth & the Gut

Research has demonstrated that nutrition plays a role in intestinal permeability and gut health, with certain nutrients supporting the integrity of the gut while others may contribute to damage.11 

Kettle & Fire Bone Broths are some of the best foods for supporting gut health. It is high in many of the important nutrients that research shows can heal the gut lining. This includes:

  • Collagen
  • Gelatin
  • Amino acids
  • Glutamine
  • Glycine
  • Arginine


Collagen is the most abundant protein in the body, and studies show that ingestion of collagen may improve barrier function and digestive symptoms.12,13 A study investigating the use of collagen in 36 women with an average age of 46 found that women reported a beneficial effect on symptoms of intestinal pain and bloating on a medical symptom questionnaire.

The same study also interviewed US-based healthcare practitioners who cited that their patients experienced a “reduction in bloating, stomach cramps, flatulence, and acid reflux, as well as improvement in irregular bowel movements when used daily for a period of at least 6 to 8 weeks.”13

While the study does have limitations, it suggests improvements in GI symptoms and warrants further investigations on the benefits of dietary intake of collagen on the health of the gut.  


Gelatin is a protein made from collagen and boasts the presence of some pretty important amino acids: proline, hydroxyproline, and glycine. Animal trials demonstrated that bovine-derived gelatin peptides exerted an anti-inflammatory effect, positively impacted tight junction proteins, improved the microbiome composition, and helped protect the gastric lining.14,15 In humans, it has been noted that gelatin protects the gut by forming protein-rich fils that line the gut walls.16 

Amino Acids & Gut Health

Research suggests that some amino acids may play a therapeutic role in gut health.17 Bone broth, collagen, and gelatin are high in some of these important amino acids.


Glutamine is the most abundant amino acid in the body and is considered conditionally essential. During times of physical stress, the body’s demand for glutamine is greater than the ability to synthesize it.18

The role of glutamine in intestinal health is well-established, as it acts as a fuel source for the enterocyte.19 As far back as the 1990s, the Lancet published a trial demonstrating how the addition of glutamine to patients' nutritional care prevented the deterioration of gut permeability and preserved the structure of the mucosal lining.20

Since then, it has continued to be studied for its role in intestinal health, and healthcare practitioners have used bone broth or supplemental glutamine as a way to help their patients with disorders of the gut.


Glycine is a conditionally essential amino acid found in bone broth. Clinical trials suggest that it can protect the intestinal wall from oxidative damage. In Wang et al.’s review “Amino Acids and Gut Function,” the publication highlights that glycine works by scavenging free radicals, acts as an osmoprotectant, and participates in extracellular signaling and the modification of biologically active molecules.17


The enterocyte is responsible for the synthesis of the conditionally essential amino acid arginine, with glutamate being a precursor molecule.17 Arginine is a precursor to nitric oxide (NO), which can help to reduce inflammation by regulating cytokine production.21 Wang points out that animal models have shown the benefit of NO in suppressing mucosal inflammation and that arginine can be an effective agent in improving intestinal barrier function.17 

Say Goodbye to Gut Issues.

The research is clear: using Kettle & Fire as part of your overall gut health plan can make all the difference.

Good Gut Health Starts Here

These bone broths contain specific nutrients that work together to help free you from digestive issues, pain, and other tummy troubles.

Classic Chicken
Classic Beef
Turmeric Ginger
Lemongrass Ginger

Explore More Health Benefits

Resources & References:

1. Digestive Diseases Statistics for the United States | NIDDK. National Institute of Diabetes and Digestive and Kidney Diseases. Accessed June 23, 2022.

2. Otani S, Coopersmith CM. Gut integrity in critical illness. j intensive care. 2019;7(1):17. doi:10.1186/s40560-019-0372-6

3. Vijay A, Valdes AM. Role of the gut microbiome in chronic diseases: a narrative review. Eur J Clin Nutr. 2022;76(4):489-501. doi:10.1038/s41430-021-00991-6

4. Yoo JY, Groer M, Dutra SVO, Sarkar A, McSkimming DI. Gut Microbiota and Immune System Interactions. Microorganisms. 2020;8(10):1587. doi:10.3390/microorganisms8101587

5. Mörbe UM, Jørgensen PB, Fenton TM, et al. Human gut-associated lymphoid tissues (GALT); diversity, structure, and function. Mucosal Immunol. 2021;14(4):793-802. doi:10.1038/s41385-021-00389-4

6. Gwak MG, Chang SY. Gut-Brain Connection: Microbiome, Gut Barrier, and Environmental Sensors. Immune Netw. 2021;21(3):e20. doi:10.4110/in.2021.21.e20

7. Aldars-García L, Chaparro M, Gisbert JP. Systematic Review: The Gut Microbiome and Its Potential Clinical Application in Inflammatory Bowel Disease. Microorganisms. 2021;9(5):977. doi:10.3390/microorganisms9050977

8. Shreiner AB, Kao JY, Young VB. The gut microbiome in health and in disease. Current opinion in gastroenterology. 2015;31(1):69. doi:10.1097/MOG.0000000000000139

9. Bischoff SC, Barbara G, Buurman W, et al. Intestinal permeability – a new target for disease prevention and therapy. BMC Gastroenterol. 2014;14(1):189. doi:10.1186/s12876-014-0189-7

10. Farré R, Fiorani M, Abdu Rahiman S, Matteoli G. Intestinal Permeability, Inflammation and the Role of Nutrients. Nutrients. 2020;12(4):1185. doi:10.3390/nu12041185

11. Khoshbin K, Camilleri M. Effects of dietary components on intestinal permeability in health and disease. American Journal of Physiology-Gastrointestinal and Liver Physiology. 2020;319(5):G589-G608. doi:10.1152/ajpgi.00245.2020

12. Chen Q, Chen O, Martins IM, et al. Collagen peptides ameliorate intestinal epithelial barrier dysfunction in immunostimulatory Caco-2 cell monolayers via enhancing tight junctions. Food Funct. 2017;8(3):1144-1151. doi:10.1039/C6FO01347C

13. Abrahams M, O’Grady R, Prawitt J. Effect of a Daily Collagen Peptide Supplement on Digestive Symptoms in Healthy Women: 2-Phase Mixed Methods Study. JMIR Formative Research. 2022;6(5):e36339. doi:10.2196/36339

14. Xing L, Fu L, Cao S, Yin Y, Wei L, Zhang W. The Anti-Inflammatory Effect of Bovine Bone-Gelatin-Derived Peptides in LPS-Induced RAW264.7 Macrophages Cells and Dextran Sulfate Sodium-Induced C57BL/6 Mice. Nutrients. 2022;14(7):1479. doi:10.3390/nu14071479

15. Samonina G, Lyapina L, Kopylova G, et al. Protection of gastric mucosal integrity by gelatin and simple proline-containing peptides. Pathophysiology. 2000;7(1):69-73. doi:10.1016/S0928-4680(00)00045-6

16. Ruszczyński M, Urbańska M, Szajewska H. Gelatin tannate for treating acute gastroenteritis: a systematic review. Ann Gastroenterol. 2014;27(2):121-124.

17. Wang WW, Qiao SY, Li DF. Amino acids and gut function. Amino Acids. 2009;37(1):105-110. doi:10.1007/s00726-008-0152-4

18. Lacey JM, Wilmore DW. Is glutamine a conditionally essential amino acid? Nutr Rev. 1990;48(8):297-309. doi:10.1111/j.1753-4887.1990.tb02967.x

19. Rao R, Samak G. Role of Glutamine in Protection of Intestinal Epithelial Tight Junctions. J Epithel Biol Pharmacol. 2012;5(Suppl 1-M7):47-54. doi:10.2174/1875044301205010047

20. van der Hulst RRWJ, von Meyenfeldt MF, Deutz NEP, et al. Glutamine and the preservation of gut integrity. The Lancet. 1993;341(8857):1363-1365. doi:10.1016/0140-6736(93)90939-E

21. Fritz JH. Arginine Cools the Inflamed Gut. Infection and Immunity. 2013;81(10):3500-3502. doi:10.1128/IAI.00789-13

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